Frequently Asked Questions

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Safety

The pain reliever in Advil® PM is ibuprofen, which is part of a class of drugs called non-steroidal anti-inflammatory drugs (also known as NSAIDs). Advil® PM does not contain acetaminophen, the active ingredient in Tylenol® PM, and it’s been proven that Advil® PM gives you a better night’s sleep than Tylenol® PM because you’ll spend less time lying awake with annoying aches and pains and more time asleep.
Diphenhydramine Citrate is a gentle sleep aid that helps you get a full night’s sleep. It has been used for over 50 years, and has had a long history of safe and effective use when used as directed.
Each Advil® PM caplet contains 200 mg of ibuprofen and 38 mg of diphenhydramine citrate. This patented bi-layer formula not only reduces your pain, it shortens the time it takes to fall asleep and increases the duration of your sleep.
Ibuprofen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAID) that has been relieving pain for quite a while. In fact, the first clinical trials of ibuprofen began in February 1966 and over 30 years of clinical studies prove that ibuprofen, the pain reliever in Advil® PM, is effective on pain.
NSAIDs, nonsteroidal anti-inflammatory drugs, are a group of chemical compounds that often are chemically unrelated but share therapeutic actions such as analgesic (pain-relieving) and antipyretic (fever-reducing) effects. Ibuprofen is just one drug in the NSAID class.
For more than 30 years, extensive consumer use and numerous clinical studies have shown that, ibuprofen, the pain reliever in Advil® PM, and diphenhydramine, the sleep aid in Advil® PM, are both safe and effective when used as directed.
Please refer to the full product labeling for additional safety information related to Advil® PM.
It is not recommended to use the product past its expiration date, as the effectiveness of the ingredients is only assured until the date printed on the package.
The FDA has asked all manufacturers of over-the-counter (OTC) non-aspirin NSAIDS (nonsteroidal anti-inflammatory drugs) to update the drug facts label warnings related to cardiovascular risk. This includes ibuprofen (such as Advil® PM and Motrin® PM) and naproxen sodium (such as Aleve® PM). The labeling on our website has been updated to reflect this new guidance. As retailers restock their Advil® PM inventory, you will see the updated label on our product packaging. Continue to follow the directions for use on the product packaging you purchased.
We have updated our website to reflect the new logo and packaging design of Advil® PM. You may see the previous logo/packaging in-store and online until retailers restock their inventory. Continue to follow the directions for use on the product you purchased.

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Pfizer Inc., PO Box 1043
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