Frequently Asked Questions

Browse the topics below to find the information that's important to you.

Allergies

Advil® PM Liqui-Gels® contains a wheat derivative, and are not gluten-free. You should check with your doctor if you have any concerns about taking this product.

Side Effects

All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome: Constipation; diarrhea; dizziness; drowsiness; dry mouth, throat, and nose; excitability; gas; headache; heartburn; nausea; stomach pain or upset; thickening of mucus in nose or throat.
Ibuprofen may cause ulcers but usually at higher prescription doses or when administered for long periods of time. Studies have proven that Advil® PM products are safe and effective when taken as directed. If you have a history of stomach problems, such as heartburn, consult your doctor before using Advil® PM products.
When taken according to the label, adverse effects of Advil® PM products on the liver are uncommon. Effects of ibuprofen on the liver are rare but may include liver disorder, abnormal liver function, hepatitis and jaundice, and they may occur at higher than recommended over-the-counter (OTC) doses. Consult your physician if you have liver cirrhosis before taking Advil® PM products or if you have any other concern about taking Advil® PM products.

Ingredients

Each Advil® PM Liqui-Gels® capsule contains 200 mg of ibuprofen and 25 mg of diphenhydramine hydrochloride, a gentle, non-habit forming sleep aid. The ibuprofen relieves pain over several hours, while the diphenhydramine helps you get a full night’s sleep. The combination of these ingredients not only reduces your pain, it shortens the time it takes to fall asleep and increases the duration of your sleep. The result: a better night's sleep.
Each Advil® PM caplet contains 200 mg of ibuprofen and 38 mg of diphenhydramine citrate, a gentle sleep aid. The ibuprofen relieves pain, while the diphenhydramine helps you get a full night’s sleep. The combination of these ingredients not only reduces your pain, it shortens the time it takes to fall asleep and increases the duration of your sleep. The result: a better night's sleep.
NSAIDs, nonsteroidal anti-inflammatory drugs, are a group of chemical compounds that often are chemically unrelated but share therapeutic actions such as analgesic (pain-relieving) and antipyretic (used to reduce fever) effects.
"Solubilized ibuprofen" is ibuprofen that has been completely dissolved in a liquid center inside a soft capsule shell. In the case of Advil® PM Liqui-Gels®, the solubilized ibuprofen is in a liquid center inside a soft capsule shell.

Products

Pain cannot only delay the onset of sleep, it can cause frequent or early morning awakenings and prevent you from getting the deep, restful sleep you need. That’s why, even if you do get some shut-eye, you may not feel rested.
The active ingredients in Advil PM® include ibuprofen, an NSAID, and diphenhydramine, a gentle, non-habit forming sleep-aid. The active ingredients in Aleve PM® include naproxen, also an NSAID, and diphenhydramine. Both of these medications include a nonsteroidal anti-inflammatory drug (NSAID) for pain relief in addition to a sleep aid. The difference between these products is the active ingredient (the NSAID), which determines the dosing in the product.
If pain is keeping you from falling asleep, a product that combines a pain reliever with a non-habit forming sleep aid (like Advil® PM) can help ease your pain and help you fall asleep and stay asleep.
Advil PM® has a pain reliever, ibuprofen, in addition to a gentle, non-habit forming sleep aid, diphenhydramine. ZzzQuil® is a sleep-aid that helps with occasional sleeplessness but has no pain reliever in it to help relieve the aches and pains that may keep you up at night.
Advil®PM was the first non-habit forming nighttime pain reliever to combine the #1
selling pain reliever (Ibuprofen) with the #1 selling sleep aid
(Diphenhydramine)‡‡. Whether you suffer from occasional muscle aches, backache,
minor arthritis, or other aches and pain, nothing is proven to help you
fall asleep faster & stay asleep longer. Advil®PM gives you a better night’s sleep than Tylenol PM because you’ll spend less time lying awake with annoying aches and pains and sleep the whole night.
Both of these medications include the same active ingredients but are conveniently provided in two different forms. Advil PM® caplets are a solid dose form with ibuprofen 200 mg and diphenhydramine citrate 38 mg per tablet. Advil PM® Liqui-gels are liquid-filled capsules with ibuprofen 200 mg and
diphenhydramine hydrochloride 25 mg per capsule. The amount of diphenhydramine base (active ingredient) is the same in both dose forms.
Like any drug you become dependent on, Advil® PM can cause addiction problems. While the drug itself is not considered to be "addictive", the associations people can form with the drug and its results can create a dependency.
Avoid drinking alcohol. Advil® PM contains diphenhydramine, which may cause drowsiness - alcohol may intensify this side effect temporarily.
Most retail grocery, pharmacy and convenience stores carry a variety of Advil® PM products. Please check our “Buy Now” page on this website to locate a store near you that carries our products. You may also find online stores that carry the products on this page as well.
Advil® PM caplets are available in package sizes of 200, 120, 80, 40 and 20 caplets. Plus, there’s a convenient travel size of 4 caplets. Advil® PM Liqui-Gels® are available in package sizes of 80, 40 and 20 capsules.

Dosing

Yes, you may take Advil® during the day and Advil PM® at night. However, since both products contain 200 mg of ibuprofen, a total daily dose (24 hours) of 1200 mg should not be exceeded when both products are combined. Advil PM® also contains diphenhydramine and a maximum daily dose (24 hours) of 50 mg should not be exceeded. Please refer to your healthcare provider for medical advice.
This product can be used for up to 10 days for pain. If pain gets worse or lasts more than 10 days, stop use and ask a doctor.
The two active ingredients in Advil® PM products, ibuprofen and diphenhydramine, have a long history of safe and effective use when used as directed. Ibuprofen has been available for over-the-counter use for over 30 years and diphenhydramine has been used for over 50 years.
The recommended dose of Advil® PM Liqui-Gels® is two capsules at bedtime, for adults and children 12 years and older. The two capsule dose contains a combined total of 400 mg of ibuprofen and 50 mg of diphenhydramine hydrochloride. You should not take more than 2 capsules in 24 hours. Stop use and ask a doctor if: pain gets worse or lasts more than 10 days or if sleeplessness persists continuously for more than 2 weeks.
The recommended dose of Advil® PM caplets is two caplets at bedtime, for adults and children 12 years and older. The two caplet dose contains a combined total of 400 mg of ibuprofen and 76 mg of diphenhydramine citrate. You should not take more than 2 capsules in 24 hours. Stop use and ask a doctor if: pain gets worse or lasts more than 10 days or if sleeplessness persists continuously for more than 2 weeks.

Safety

The pain reliever in Advil® PM is ibuprofen, which is part of a class of drugs called non-steroidal anti-inflammatory drugs (also known as NSAIDs). Advil® PM does not contain acetaminophen, the active ingredient in Tylenol® PM, and it’s been proven that Advil® PM gives you a better night’s sleep than Tylenol® PM because you’ll spend less time lying awake with annoying aches and pains and more time asleep.
Diphenhydramine Citrate is a gentle, non-habit forming sleep aid that helps you get a full night’s sleep. It has been used for over 50 years, and has had a long history of safe and effective use when used as directed.
Each Advil® PM caplet contains 200 mg of ibuprofen and 38 mg of diphenhydramine citrate. This patented bi-layer formula not only reduces your pain, it shortens the time it takes to fall asleep and increases the duration of your sleep.
Ibuprofen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAID) that has been relieving pain for quite a while. In fact, the first clinical trials of ibuprofen began in February 1966 and over 30 years of clinical studies prove that ibuprofen, the pain reliever in Advil® PM, is effective on pain.
NSAIDs, nonsteroidal anti-inflammatory drugs, are a group of chemical compounds that often are chemically unrelated but share therapeutic actions such as analgesic (pain-relieving) and antipyretic (fever-reducing) effects. Ibuprofen is just one drug in the NSAID class.
For more than 30 years, extensive consumer use and numerous clinical studies have shown that, ibuprofen, the pain reliever in Advil® PM, and diphenhydramine, the sleep aid in Advil® PM, are both safe and effective when used as directed.
Please refer to the full product labeling for additional safety information related to Advil® PM.
It is not recommended to use the product past its expiration date, as the effectiveness of the ingredients is only assured until the date printed on the package.

Interactions

You should consult a doctor or pharmacist before use if you are: Taking sedatives or tranquilizers or any other sleep aid Taking any other drug containing an NSAID (prescription or nonprescription) Under a doctor’s care for any continuing medical illness Taking any other antihistamines Taking a blood-thinning (anticoagulant) or steroid drug Taking aspirin for heart attack or stroke Taking any other drug Please see product labeling for complete warnings information.
If you are taking prescription medication, you should discuss using Advil® PM products with your doctor or pharmacist. This is especially important if you have any condition that requires you taking a prescription medication.
Advil® PM products can be taken with nutritional supplements. However, if you are taking nutritional supplements, it is recommended that you discuss this with your physician or pharmacist before taking Advil® PM products.
We recommend that you contact your physician if you are taking other specific medications before taking Advil® PM products. Advil® PM products should not be taken with any other product containing ibuprofen, naproxen, Acetaminophen, aspirin or with any other product containing diphenhydramine, even one used on skin.
Herbal supplements may contain complex formulations of ingredients that can interact with medications. Therefore, it is recommended that before taking Advil® PM products you should consult your physician or pharmacist about any herbal supplements that you are taking.
It is not necessary to take Advil® PM products with food, however, take them with food or milk if an upset stomach occurs. Consult your physician before taking any NSAID if you have a history of stomach problems such as heartburn, upset stomach or stomach pain.

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