Frequently Asked Questions

Browse the topics below to find the information that's important to you.

Allergies

I am allergic to gluten. Is it all right for me to take this product?
Advil® PM Liqui-Gels® contains a wheat derivative, and are not gluten-free. You should check with your doctor if you have any concerns about taking this product.

Side Effects

What are some possible side effects of Advil® PM Liqui-Gels®?
All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:  Constipation; diarrhea; dizziness; drowsiness; dry mouth, throat, and nose; excitability; gas; headache; heartburn; nausea; stomach pain or upset; thickening of mucus in nose or throat.
Do Advil® PM products cause ulcers?
Ibuprofen may cause ulcers but usually at higher prescription doses or when administered for long periods of time. Studies have proven that Advil® PM products are safe and effective when taken as directed. If you have a history of stomach problems, such as heartburn, consult your doctor before using Advil® PM products.
What effect will Advil® PM products have on the liver?
When taken according to the label, adverse effects of Advil® PM products on the liver are uncommon. Effects of ibuprofen on the liver are rare but may include liver disorder, abnormal liver function, hepatitis and jaundice, and they may occur at higher than recommended over-the-counter (OTC) doses. Consult your physician if you have liver cirrhosis before taking Advil PM products or if you have any other concern about taking Advil® PM products.

Ingredients

What are the active ingredients in Advil® PM Liqui-Gels®?
Each Advil® PM Liqui-Gels capsule contains 200 mg of ibuprofen and 25 mg of diphenhydramine hydrochloride, a gentle sleep aid. The ibuprofen relieves pain over several hours, while the diphenhydramine helps you get a full night’s sleep. The combination of these ingredients not only reduces your pain, it shortens the time it takes to fall asleep and increases the duration of your sleep. The result: a better night's sleep.
What are the active ingredients in Advil® PM caplets?
Each Advil® PM caplet contains 200 mg of ibuprofen and 38 mg of diphenhydramine citrate, a gentle sleep aid. The ibuprofen relieves pain, while the diphenhydramine helps you get a full night’s sleep. The combination of these ingredients not only reduces your pain, it shortens the time it takes to fall asleep and increases the duration of your sleep. The result: a better night's sleep.
What are NSAIDs?
NSAIDs, nonsteroidal anti-inflammatory drugs, are a group of chemical compounds that often are chemically unrelated but share therapeutic actions such as analgesic (pain-relieving) and antipyretic (used to reduce fever) effects.
Do Advil® PM products contain aspirin?
No.
What is the definition of “solubilized ibuprofen”?
"Solubilized ibuprofen" is ibuprofen that has been completely dissolved in a liquid center inside a soft capsule shell. In the case of Advil® PM Liqui-Gels®, the solubilized ibuprofen is in a liquid center inside a soft capsule shell.

Products

What are the package sizes for Advil® PM products?
Advil® PM caplets are available in package sizes of 200, 120, 80, 40 and 20 caplets. Plus, there’s a convenient travel size of 4 caplets. Advil® PM Liqui-Gels® are available in package sizes of 80, 40 and 20 capsules.
How does pain affect the ability to sleep?
Pain cannot only delay the onset of sleep, it can cause frequent or early morning awakenings and prevent you from getting the deep, restful sleep you need. That’s why, even if you do get some shut-eye, you may not feel rested.
Why do I need a pain reliever with a sleep aid?
If pain is keeping you from falling asleep, a product that combines a pain reliever with a sleep aid (like Advil® PM) can help ease your pain and help you fall asleep and stay asleep.
How are Advil® PM products different than other nighttime pain relievers?
Advil® PM products were the first nighttime pain reliever with ibuprofen. Whether you have occasional muscle aches, a backache, minor arthritis pain or other aches and pains, the ibuprofen in Advil® PM’s patented bi-layer formula helps ease your pain so you can fall asleep faster and stay asleep longer. Advil® PM gives you a better night's sleep than Tylenol PM® because you'll spend less time lying awake with annoying aches and pains and more time asleep.
Will Advil® PM heal my arthritis?
There is no known cure for arthritis. Advil® (at the recommended nonprescription dose) can provide temporary relief of minor pain associated with arthritis. For more information on the appropriate treatment of arthritis, consult your physician.
Is Advil® PM addictive?
Like any drug you become dependent on, Advil® PM can cause addiction problems. While the drug itself is not considered to be "addictive", the associations people can form with the drug and its results can create a dependency.
Can I take Advil® PM caplets with alcohol?
Avoid drinking alcohol. Advil® PM contains diphenhydramine, which may cause drowsiness - alcohol may intensify this side effect temporarily.
Where can I purchase Advil® PM products?
Most retail grocery, pharmacy and convenience stores carry a variety of Advil® PM products. Please check our “Buy Now” page on this website to locate a store near you that carries our products. You may also find online stores that carry the products on this page as well.

Dosing

What is the safety history of the ingredients in Advil® PM products?
The two active ingredients in Advil® PM products, ibuprofen and diphenhydramine, have a long history of safe and effective use when used as directed. Ibuprofen has been available for over-the-counter use for over 30 years and diphenhydramine has been used for over 50 years.
The recommended dose of Advil® PM Liqui-Gels® is two capsules at bedtime, for adults and children 12 years and older. The two capsule dose contains a combined total of 400 mg of ibuprofen and 50 mg of diphenhydramine hydrochloride. You should not take more than 2 capsules in 24 hours. Stop use and ask a doctor if: pain gets worse or lasts more than 10 days or if sleeplessness persists continuously for more than 2 weeks.
The recommended dose of Advil® PM caplets is two caplets at bedtime, for adults and children 12 years and older. The two caplet dose contains a combined total of 400 mg of ibuprofen and 76 mg of diphenhydramine citrate. You should not take more than 2 capsules in 24 hours. Stop use and ask a doctor if: pain gets worse or lasts more than 10 days or if sleeplessness persists continuously for more than 2 weeks.

Safety

Can I use Advil® PM products beyond the expiration date?
It is not recommended to use the product past its expiration date, as the effectiveness of the ingredients is only assured until the date printed on the package.

Interactions

Can I take Advil® PM products with other medications?
You should consult a doctor or pharmacist before use if you are: Taking sedatives or tranquilizers or any other sleep aid Taking any other drug containing an NSAID (prescription or nonprescription) Under a doctor’s care for any continuing medical illness Taking any other antihistamines Taking a blood-thinning (anticoagulant) or steroid drug Taking aspirin for heart attack or stroke Taking any other drug Please see product labeling for complete warnings information.
Will this product interact with my prescription medication?
If you are taking prescription medication, you should discuss using Advil® PM products with your doctor or pharmacist. This is especially important if you have any condition that requires you taking a prescription medication.
Can Advil® PM products be taken with nutritional supplements?
Advil® PM products can be taken with nutritional supplements. However, if you are taking nutritional supplements, it is recommended that you discuss this with your physician or pharmacist before taking Advil® PM products.
Can Advil® PM products be taken with other over-the-counter (OTC) medications, e.g. other analgesics, antibiotics, cold remedies, etc.?
We recommend that you contact your physician if you are taking other specific medications before taking Advil® PM products. Advil® PM products should not be taken with any other product containing ibuprofen, naproxen, Acetaminophen, aspirin or with any other product containing diphenhydramine, even one used on skin.
Can Advil® PM products be taken with herbal supplements?
Herbal supplements may contain complex formulations of ingredients that can interact with medications. Therefore, it is recommended that before taking Advil PM products you should consult your physician or pharmacist about any herbal supplements that you are taking.
Do I have to take Advil® PM products with food?
It is not necessary to take Advil® PM products with food, however, take them with food or milk if an upset stomach occurs. Consult your physician before taking any NSAID if you have a history of stomach problems such as heartburn, upset stomach or stomach pain.

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