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  2. What is difference between tylenol PM and Advil PM?

Frequently Asked Questions: Advil PM vs Tylenol PM

  • What’s the difference between Tylenol PM and Advil PM?

    The pain reliever in Advil PM is ibuprofen, which is part of a class of drugs called non-steroidal anti-inflammatory drugs (also known as NSAIDs). Advil PM does not contain acetaminophen, the active ingredient in Tylenol PM, and it’s been proven that Advil PM gives you a better night’s sleep than Tylenol PM because you’ll spend less time lying awake with annoying aches and pains and more time asleep.